Deepening constantly understanding of protein folding problem
نویسندگان
چکیده
منابع مشابه
Understanding protein non-folding.
This review describes the family of intrinsically disordered proteins, members of which fail to form rigid 3-D structures under physiological conditions, either along their entire lengths or only in localized regions. Instead, these intriguing proteins/regions exist as dynamic ensembles within which atom positions and backbone Ramachandran angles exhibit extreme temporal fluctuations without sp...
متن کاملThe protein folding problem.
The "protein folding problem" consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years. Now, foldable proteins and nonbiological polymers are being designed routinely and ...
متن کاملUnderstanding ensemble protein folding at atomic detail.
It has long been known that a protein's amino acid sequence dictates its native structure. However, despite significant recent advances, an ensemble description of how a protein achieves its native conformation from random coil under physiologically relevant conditions remains incomplete. Here we present a detailed all-atom model with a transferable potential that is capable of ab initio foldin...
متن کاملUnderstanding protein folding: small proteins in silico.
Recent improvements in methodology and increased computer power now allow atomistic computer simulations of protein folding. We briefly review several advanced Monte Carlo algorithms that have contributed to this development. Details of folding simulations of three designed mini proteins are shown. Adding global translations and rotations has allowed us to handle multiple chains and to simulate...
متن کاملSimple Models of the Protein Folding Problem
The protein folding problem has attracted an increasing attention from physicists. The problem has a avor of statistical mechanics, but possesses the most common feature of most biological problems – the profound e ects of evolution. I will give an introduction to the problem, and then focus on some recent work concerning the so-called “designability principle”. The designability of a structure...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Structure and Dynamics
سال: 2013
ISSN: 0739-1102,1538-0254
DOI: 10.1080/07391102.2012.748527